CRRT Trials of the Week: RENAL & IDEAL-ICU

Special Guest: Linda Awdishu, PharmD, MAS

Linda Awdishu joins me to highlight two landmark studies related to the use of continuous renal replacement therapy (CRRT) in the critically ill.

We discuss renal replacement therapy, compare modalities, and review the history of CRRT as an introduction. Then we review two studies: “Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients: RENAL study” published in 2009 and “Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis: IDEAL-ICU study” published in 2018, both in the New England Journal of Medicine.

Would these findings be replicated in other populations, do we have answers about the most appropriate effluent rate and when to initiate CRRT in the critically ill, findings from both studies, future research priorities, and much, much more!

References list: https://pharmacytodose.files.wordpress.com/2023/10/crrt-tow-references.pdf

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