Vitamin D and Statin Interactions, Deprescribing Overmedication, and Cancer Cell Mitochondria Theft

Broadcast from KSQD, Santa Cruz on 7-03-2025:

• Dr. Dawn responds to an email about vitamin D and statin interactions, explaining how statins may prevent vitamin D's longevity benefits by interfering with CoQ10 production. She references a study showing vitamin D preserved telomeres and prevented aging over 3-4 years, but benefits disappeared in statin users. For borderline high LDL, she recommends testing for large versus small particles and oxidized LDL rather than treating with statins or red yeast rice. Red yeast rice may also block CoQ10 production, potentially negating vitamin D benefits.
• She discusses the critical problem of overmedication in elderly patients through a story of a 75-year-old taking 21 prescription drugs who improved dramatically when reduced to eight medications. Multiple specialists practicing standard care in isolation create dangerous polypharmacy without coordination. HIPAA privacy laws prevent medication sharing between providers, while electronic medical records remain siloed and incompatible.
• England's pilot program will provide whole genome screening for every newborn within 10 years, assessing hundreds of disease risks and enabling personalized medicine. While beneficial for identifying genetic disorders and drug metabolism variations like 2D6 mutations affecting tamoxifen effectiveness, Dr. Dawn expresses concern about government surveillance implications. Unlike voluntary phone tracking, this represents involuntary comprehensive genetic monitoring of citizens unable to provide informed consent.
• She describes alarming research showing cancer cells steal mitochondria from nerve cells by extending tubes and sucking out energy-producing organelles. This behavior helps cancer cells survive the hostile journey through bloodstream during metastasis. Turbocharged cancer cells with stolen mitochondria generate more energy and survive better when subjected to physical stress mimicking bloodstream travel.
• Dr. Dawn explores the parasitic amoeba Entamoeba histolytica, which causes intestinal disease but can become invasive, liquefying organs through tissue destruction. The parasite kills cells without eating them immediately, then consumes fragments and displays stolen cellular proteins on its surface to fool the immune system, potentially leading to CRISPR-based treatments or targeted drugs.
• She discusses converting plastic waste into acetaminophen using modified E. coli bacteria. Researchers chemically degrade PET plastic into precursor molecules, then use bacterial enzymes to complete synthesis into paracetamol with 92% efficiency. This transforms environmental waste into globally important medication, though she notes acetaminophen risks for regular drinkers due to toxic liver metabolites.
• MIT research reveals that AI writing assistance reduces brain engagement, memory, and sense of authorship. Students using ChatGPT showed lower neural connectivity in memory, attention, and executive function networks over four months. AI users retained less information and struggled to quote from their own essays. Dr. Dawn compares this to physical atrophy, emphasizing that cognitive challenge strengthens neural pathways like exercise strengthens muscles.
• She warns about fluoroquinolone antibiotics causing aortic aneurysm ruptures, in addition to known risks of tendon ruptures and retinal detachment. People with dilated aortas, hypertension history, or smoking should avoid these drugs entirely. This represents new information that wasn't widely known among primary care physicians, highlighting the importance of continuing medical education.
• Research shows celecoxib (Celebrex) cuts colon cancer recurrence rates in half for patients with circulating tumor DNA, but provides no benefit without detectable residual disease. This anti-inflammatory drug appears to impair cancer's ability to thrive in metastatic conditions. The finding supports using circulating tumor DNA testing to identify who needs targeted therapy rather than treating everyone.
• Dr. Dawn concludes with surprising research showing chronic inflammation during aging occurs only in industrialized societies. Studies comparing indigenous communities from Bolivian Amazon and Malaysia with populations from Italy and Singapore found inflammatory cytokines increase with age only in industrialized groups.