Core IM | Internal Medicine Podcast

#108 Drug Fever and Antibiotic-Associated Neurotoxicity: Gray Matters Segment

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Jul 13, 2022
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ADVICE

Distinguishing Sepsis from Drug Fever

  • Consider a patient's trajectory to distinguish sepsis from drug fever.
  • Does the clinical course align with a typical infectious process?
INSIGHT

Consider Non-Infectious Mimics

  • If a thorough workup reveals no infection source, consider non-infectious mimics like drug fever.
  • Common infectious sources are usually easy to find in the ICU.
ADVICE

Common Drug Fever Culprits

  • Beta-lactams are the most common antibiotics causing drug fever, followed by tetracyclines like minocycline.
  • Consider antiepileptic drugs as well.
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