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The Drug Discovery World Podcast
DDW Highlights: 11 March 2024
Mar 11, 2024
This podcast highlights the discovery of antibodies targeting a new influenza target, a novel bi-specific antibody for inflammatory disorders, advancements in severe asthma management, and the safety and efficacy of D'Ananamab for Alzheimer's disease.
15:36
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Quick takeaways
- Antibody medications show anti-tumor activity by targeting immune responses against tumor cells.
- Discovery of antibodies targeting the neuraminidase head region of influenza virus opens new treatment possibilities.
Deep dives
Promising Safety Data and Anti-Tumor Activity in Advanced Cancer Patients
A recent early phase clinical trial featured a combination of antibody-based medications that showed promising safety data and anti-tumor activity in individuals with advanced cancer. The medications, CS 1002 and CS 1003, target immune responses against tumor cells. Notably, CS 1002 increases T-immune cell activation and proliferation by binding to CTLA4, while CS 1003 blocks the programmed cell death protein 1. The study involved various dosing schedules and demonstrated positive responses in different types of tumors.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode