
StarTalk Radio What Loneliness Does To Your Brain with Ben Rein
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Oct 31, 2025 Join neuroscientist Ben Rein, author of Why Brains Need Friends, as he dives into the fascinating science of loneliness. He distinguishes between isolation and loneliness, revealing how the latter triggers stress and affects brain chemistry with hormones like oxytocin and serotonin. Discover the stark contrast between virtual and in-person interactions and how they impact our mood. Rein also discusses societal causes of the loneliness epidemic and offers practical tips to help those feeling isolated, emphasizing the importance of community and connection.
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Loneliness Versus Isolation
- Loneliness is a subjective feeling while isolation is the objective state of being alone.
- You can be lonely in a crowd or content when physically alone depending on your social needs.
Isolation Activates Stress Biology
- Isolation triggers the body's stress response and raises cortisol levels.
- The brain signals danger when removed from the tribe, making isolation biologically stressful.
Social Interaction Is Neurochemical Reward
- Positive social interactions release oxytocin, serotonin, and dopamine as social rewards.
- These neurotransmitters reinforce social behavior like eating reinforces nutrition.




