Sawbones: A Marital Tour of Misguided Medicine Sawbones: Methylene Blue
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Oct 28, 2025 In this episode, Dr. Sydnee dives into the colorful history of methylene blue, originally a lab dye turned potential cancer treatment. She explores its early uses and the intriguing science behind its redox properties. The podcast covers claims of methylene blue’s effects against malaria and cyanide poisoning, while highlighting its approved use for treating methemoglobinemia. Sydnee warns about the dangers of unverified medical advice, especially when popularized by influencers, ultimately advocating for evidence-based medicine.
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From Dye To Medical Tool
- Methylene blue was invented as a dye and later repurposed for medical staining and study.
- Staining revealed selective binding to organisms, prompting early therapeutic experiments.
Matilda Brooks’ Unpaid Breakthrough
- Dr. Matilda Brooks researched methylene blue but faced anti-nepotism pay restrictions.
- She continued unpaid work and discovered redox properties that later shaped medical uses.
Redox Property Explains Medical Effects
- Methylene blue is a redox dye that changes color when reduced and can accept or donate electrons.
- That redox ability lets it bypass mitochondrial blocks like those caused by cyanide.