OncoPharm Etoposide
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Mar 28, 2019 Discover the fascinating origins of etoposide, derived from the mayapple plant! Dive into its role as a topoisomerase II inhibitor and how it revolutionized cancer treatment since FDA approval in 1983. There's a deep dive into dosage regimens and the balance between efficacy and toxicities. Plus, enjoy some entertainingly unnecessary historical tidbits about podophyllotoxins. A blend of science and captivating stories awaits!
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Etoposide's Botanical Origins
- Etoposide originates from pedophilotoxins found in the Mayapple plant, historically used for various medical purposes.
- Its history includes treatments for cancer, emetic uses, and even being part of patent medicines in the 1800s and 1900s.
Etoposide's Mechanism of Action
- Etoposide acts as a topoisomerase 2 poison causing double-strand DNA breaks that induce cell cycle arrest.
- Persistent DNA breaks lead to apoptosis, making etoposide a cell cycle-specific agent, especially effective during DNA synthesis phase.
Etoposide Use in Organ Dysfunction
- Use caution with etoposide in patients with both liver and kidney dysfunction especially if albumin is low.
- Low albumin increases free drug fraction, leading to higher toxicity risks in compromised organs.
