46brooklyn is a group of pharmacy experts who set out to educate others about what they had learned about the frustrating complexity of the U.S. drug pricing system. 

As 46brooklyn dug into the pharmaceutical supply chain, Ohio began uncovering hundreds of millions of dollars in state overspending on prescription drugs through its Ohio Medicaid program. 46brooklyn's founders had begun doing data analytics and research to help uncover massive disconnects between pharmacy reimbursements, the actual costs of prescription drugs, and what the state of Ohio was getting charged through its state Medicaid program.

Ever since, 46brooklyn has spearheaded a national push for more transparency into the pharmaceutical supply chain, particularly the role played by Pharmacy Benefit Managers (PBMs).