Dr. Sindhu Johnson discusses the 2023 ACR guidelines for monitoring and treating interstitial lung disease in rheumatic diseases, including screening methods, monitoring frequency, and treatment options. The chapter highlights the importance of collaborative management between rheumatologists and pulmonologists, explores various treatment options and recommendations for specific conditions, and emphasizes the importance of early detection.
The 2023 ACR guidelines recommend screening and monitoring for interstitial lung disease (ILD) in systemic autoimmune rheumatic disease patients, using pulmonary function tests, CT scans, and ambulatory desaturation testing.
The guideline development process involved a rigorous methodology and collaboration with various medical professionals and patient panels, highlighting the need for collaborative management between rheumatologists and pulmonologists.
The guidelines provide treatment recommendations for systemic autoimmune rheumatic diseases with ILD, including preferred first-line therapies and caution against long-term use of glucocorticoids in systemic sclerosis ILD.
Deep dives
Screening and Monitoring for ILD in Systemic Autoimmune Rheumatic Diseases
The newly released 2023 ACR guidelines emphasize the importance of screening and monitoring for interstitial lung disease (ILD) in people with systemic autoimmune rheumatic diseases. The guidelines recommend screening patients with systemic sclerosis, inflammatory myopathies, mixed connective tissue disease, rheumatoid arthritis, and Shogren's syndrome. The guidelines suggest using pulmonary function tests (including lung volumes and diffusion capacity) and high-resolution CT scans for screening and monitoring. Additionally, ambulatory desaturation testing is recommended to be performed in collaboration with pulmonologists for co-management of patients with diagnosed ILD. The guidelines also address the challenges of defining patient populations, determining screening frequencies, and choosing appropriate monitoring tests.
Development of the Guidelines
The creation of the guidelines involved a rigorous process that incorporated the GRADE methodology. The guideline development involved a core team, a literature review team, a patient panel, and a voting panel consisting of rheumatologists, pulmonologists, radiologists, and patients. The development process took over two years and included reviewing evidence, evaluating patient values and preferences, and formulating recommendations. The guidelines were designed to provide guidance for clinicians who care for people at risk of developing ILD and those who have been diagnosed with ILD. The guidelines also highlight the need for collaborative management between rheumatologists and pulmonologists.
Key Recommendations for Screening
The guidelines recommend screening nearly all patients with systemic sclerosis and mixed connective tissue disease due to their high risk of developing ILD. The guidelines advise a risk-based approach for screening patients with rheumatoid arthritis and Shogren's syndrome, taking into consideration factors such as rheumatoid factor, CCP antibody, smoking status, age of onset, and disease activity. While the guidelines suggest pulmonary function tests and high-resolution CT scans for screening, they emphasize that these tests should be discussed and individualized by rheumatologists in collaboration with patients.
Treatment Recommendations
The guidelines provide treatment recommendations for various systemic autoimmune rheumatic diseases with ILD. The recommendations include preferred first-line therapies, such as mycophenolate, rituximab, and tocilizumab, depending on the specific disease. The guidelines also highlight the use of glucocorticoids as short-term bridging therapy, but strongly recommend against their long-term use in systemic sclerosis ILD due to the risk of scleroderma renal crisis. Additionally, the guidelines suggest considering other interventions, such as exercise, palliative care, physiotherapy, and supplemental oxygen, to support patient management.
Future Research and Updates
The guidelines acknowledge the need for future research in understanding the different phenotypes of ILD and identifying predictive biomarkers for risk assessment and treatment selection. The authors of the guidelines envision a living guideline model in which new evidence can be incorporated in real-time to ensure the recommendations remain up to date. They also emphasize the importance of clinical judgment and individualized treatment decisions based on patient factors and preferences.
The weekend of Convergence 2023 continues! Dr. Sindhu Johnson presented the new 2023 ACR Interstitial Lung Disease Guidelines (which can be found here ) and joins us today as its first author. Learn all about the recommendations, monitoring, how to approach treatment and when to change it as well as what gaps were noticed that inspired the new guidelines and the intent of the guidelines going forward. Enjoy, and we’ll see you tomorrow for another great episode at Convergence!
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