Over 40 Fitness Hacks 590: Brad Pitzele - Rebuilding Health with Oxygen: The Science Behind EWOT
Rebuilding Health with Oxygen: The Science Behind EWOT
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Brad Pitzele - EWOT (Exercise While On Oxygen Therapy)
YouTube: @OneThousandRoadsHQ
In this episode of Over 40 Fitness Hacks, host Brad Williams sits down with Brad Pitzele, founder of One Thousand Roads, to explore Exercise with Oxygen Therapy (EWOT)—a powerful biohacking modality that combines cardio exercise with oxygen enrichment to boost health, performance, and longevity.
Brad shares his personal battle with autoimmune arthritis and Lyme disease, a journey that began over a decade ago. After years of medication cycles, painful symptoms, and even a bout with melanoma, he sought alternative healing paths. Conventional treatments offered no long-term relief, leading him to research deeper into root causes and natural recovery methods.
When a doctor suggested trying hyperbaric oxygen therapy or EWOT, Pitzele balked at the cost and accessibility of hyperbaric chambers. Instead, he built his own EWOT system, experienced dramatic recovery over several months, and eventually founded One Thousand Roads in 2018 to make the technology affordable and accessible.
EWOT involves 15 minutes of moderate cardiovascular exercise while breathing near-pure oxygen through a mask connected to a large oxygen reservoir. Key points:
Uses oxygen concentrators to fill a 1,000-liter reservoir.
Enables oxygen delivery far beyond what standard machines can supply.
Can be used with any stationary cardio equipment (bike, treadmill, rebounder, etc.).
Requires only standard electrical outlets and minimal setup space.
Pitzele explains that as we age, “inflammaging” causes microscopic capillaries to constrict, restricting oxygen delivery and forcing cells into low-energy, anaerobic states. EWOT reverses this by:
Reoxygenating plasma to reach starved tissues.
Reducing inflammation and restoring blood flow.
Reactivating mitochondria (cellular powerhouses) and promoting new mitochondrial growth.
Boosting VO₂ max, endurance, and recovery.
Enhancing detoxification, as oxygen helps flush toxins and lactic acid.
Supporting fat burning and overall energy production.
Unlike hyperbaric oxygen, which relies on external pressure, EWOT uses exercise-driven oxygen demand for faster, more efficient absorption.
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