FoundMyFitness #079 Blood-Brain Barrier Dysfunction in Alzheimer’s Disease and Dementia | Axel Montagne, Ph.D.
82 snips
Feb 28, 2023 Dr. Axel Montagne, a Chancellor's fellow at the UK Dementia Research Institute, dives into the urgent issue of blood-brain barrier dysfunction linked to Alzheimer’s and dementia. He reveals how small blood vessel health is crucial for preventing cognitive decline and discusses early biomarkers for intervention. The conversation touches on the limitations of targeting amyloid and the significant roles of exercise and omega-3s in brain health. Montagne emphasizes the need for lifestyle changes and innovative treatments to combat neurodegeneration.
AI Snips
Chapters
Transcript
Episode notes
Vascular Dementia
- Dementia often has an early vascular component, especially in Alzheimer's disease.
- Blood vessel dysfunction, including leakiness, can be detected early and is linked to cognitive decline.
Leaky Blood-Brain Barrier
- Leaky blood-brain barriers may be more important than amyloid plaques and tau tangles in dementia.
- This breakdown allows substances from the blood to leak into the brain, potentially causing damage.
Exercise for Brain Health
- Regular aerobic exercise is crucial for maintaining brain health.
- It helps preserve small blood vessels, ensuring oxygen and nutrient supply to neurons.