John Pettersson, a researcher from Uppsala University, delves into alarming findings from China regarding viruses in fur-farmed animals like minks and raccoon dogs. He highlights their potential to cross species barriers and pose serious threats to humans. The conversation also covers the innovative Pathoplexus virus database designed for faster gene sequence sharing. Additionally, the podcast discusses a promising new monkeypox vaccine from Moderna and intriguing insights into how parental communication shapes the behavior of gull chicks.
Fur farms in China harbor diverse viruses that pose risks for zoonotic transmission to humans, highlighting the need for vigilant monitoring.
The development of Pathoplexis aims to enhance viral genetic data sharing, improving global health responses to potential outbreaks like COVID-19.
Deep dives
Viral Transmission Risks from Fur Farms
Fur farms, particularly in China, pose significant risks for viral spillovers, as highlighted by recent research. This study revealed a concerning diversity of viruses present in various animals bred for fur, including foxes and raccoon dogs, and their potential to transmit to humans. Researchers conducted opportunistic sampling of deceased animals to identify viral presence, leading to the discovery of numerous previously unrecognized viruses. The findings underscore the adaptability of these pathogens and the alarming potential for zoonotic diseases, as many viruses were identified in new host species compared to historical data.
Importance of Data Sharing for Pandemic Preparedness
Effective sharing of viral genetic data has proven crucial for managing health crises, as seen during the COVID-19 pandemic. Scientists faced challenges with existing databases that were inadequate for rapid data sharing, which highlighted the need for a more streamlined system. The introduction of Pathoplexis aims to enhance the speed and reliability of genetic sequencing data distribution, allowing quick response times in future outbreaks. By fostering a collaborative environment where scientists can share data securely and efficiently, global health readiness can be significantly improved.
Developments in mRNA Vaccines for Emerging Infections
Recent advancements in mRNA vaccine technology show promise for combating diseases like M-pox, particularly with an experimental vaccine developed by Moderna. Early animal trials have demonstrated that this vaccine effectively induces strong immune responses, offering protection against severe disease outcomes. This mRNA approach leverages years of experience in immunology research, allowing for rapid development and deployment in response to emerging viral threats. The goal is to ensure that vaccines are promptly made available to populations most at risk during outbreaks.
Prenatal Influence of Parental Communication on Chick Development
Research on gull chicks has unveiled the profound impact of prenatal exposure to parental sounds on their development and behavior. Chicks that heard communicative parents while in the egg displayed better growth and lower stress hormone responses compared to those exposed to quiet parental sounds. This study highlights the importance of social interactions even before hatching, suggesting that early auditory experiences can shape not only physiological responses but also feeding behaviors post-hatching. Such findings emphasize the intricate connections between environmental factors and animal development.
A Chinese survey of diseased animals farmed for their fur – such as mink, foxes and raccoon dogs - has revealed high levels of concerning viruses, including coronaviruses and flu viruses, many of which appear to jump easily from species to species. John Pettersson of Uppsala University discusses the threat to us humans.
We learnt early on in the Covid-19 pandemic how important the genetic details of the virus were in tracking the spread and spotting new variants. The vaccines were designed from gene sequences shared electronically long before any biological samples became available. Virologist Emma Hodcroft has teamed up with researchers around the world to develop a new virus database, Pathoplexus, to speed up the sharing of gene sequences.
Mpox outbreaks are causing concerns in Central and West Africa - particularly in the Democratic Republic of the Congo. A smallpox vaccine has started arriving, giving some protection against mpox. But there’s good news this week in an experimental vaccine developed especially for mpox by Moderna – one of the companies that brought us the mRNA vaccines against Covid-19. Galit Alter, vice president of immunology research at Moderna, tells us animal tests show that it appears to be highly effective.
And we discuss embryonic eavesdropping with Francisco Ruiz-Raya of Glasgow University. In the yellow-legged-gull, baby bird embryos that have chattier parents tend to come out chattier themselves – and likely receive better care because of their enhanced communication.
Presenter: Roland Pease
Producer: Jonathan Blackwell
Production co-ordinator: Andrew Rhys Lewis
(Image: A mink in a mink farm in the hands of a man. Credit: Neznam/Getty Images)
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