ID:IOTS - Infectious Disease Insight Of Two Specialists 76. PK: Dithering on distribution
Mar 24, 2024
Explore the complexities of drug distribution in pharmacokinetics, focusing on antibiotics like Amoxicillin and CallumShutUpicillin. Discuss the volume of distribution and plasma protein binding of antimicrobials. Delve into how low albumin levels impact drug efficacy in intensive care. Learn how molecular size and volume distribution influence antibiotic movement and clearance rates for effective treatment.
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Key Factors Affecting Drug Distribution
- Antibiotic distribution depends on vascular and drug factors like capillary permeability and drug lipophilicity.
- Drug movement from plasma to tissues varies by organ vascularity and capillary structure.
Lipophilicity Influences Distribution
- Lipophilic drugs cross cell membranes easily and distribute into fat and intracellular spaces.
- Hydrophilic drugs mainly leave plasma through fenestrated capillaries and their tissue penetration depends on pH and transport proteins.
Role of Plasma Protein Binding
- Plasma protein binding, especially to albumin, controls drug transport and free drug availability.
- Only free (unbound) drug molecules exert pharmacological effects and distribution.