ID:IOTS - Infectious Disease Insight Of Two Specialists
76. PK: Dithering on distribution
Mar 24, 2024
Explore the complexities of drug distribution in pharmacokinetics, focusing on antibiotics like Amoxicillin and CallumShutUpicillin. Discuss the volume of distribution and plasma protein binding of antimicrobials. Delve into how low albumin levels impact drug efficacy in intensive care. Learn how molecular size and volume distribution influence antibiotic movement and clearance rates for effective treatment.
41:21
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Quick takeaways
- Understanding drug distribution involves vascular and drug factors influencing antibiotic movement in the body.
- The volume of distribution and protein binding of antibiotics impact their spread and therapeutic effectiveness in treating infections.
Deep dives
Importance of Understanding Antibiotic Distribution in Treating Infections
Understanding the distribution of antibiotics in the body is crucial for effective treatment. Factors like vascular features and drug properties impact how antibiotics move from plasma to tissues. Vascular factors determine the diffusion of drugs from capillaries, influencing delivery to organs. Drug factors, such as lipophilicity and plasma protein binding, also play a role in distribution. Effective penetration into specific body compartments, like the brain or muscles, depends on the drug's properties and interaction with tissues.
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