Talk Python To Me #520: pyx - the other side of the uv coin (announcing pyx)
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Sep 23, 2025 
In this episode, Charlie Marsh, Founder and CEO of Astral, shares insights on his latest project, pyx, a revolutionary hosted Python registry. He explains how pyx enhances package management by allowing for faster and more reliable installations through smart server-client communication. The conversation also dives into the challenges of GPU-aware packaging, particularly with PyTorch, and discusses security measures and the relationship between pyx and PyPI. Prepare for a frictionless development experience!
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High-Performance Tooling Drives Adoption
- Charlie Marsh's Astral focuses on high-performance Python tooling like Ruff, UV, and TY to improve developer UX and scale to large projects.
- Performance plus better workflows drove rapid adoption and motivated full-time investment in these tools.
Speed Changes Developer Behavior
- Users often don't realize performance improvements matter until they experience them on large codebases.
- Ruff and UV demonstrated speed can change workflows and become drop-in replacements people prefer.
Install And Run Tools With UV Tool
- Use uv tool to install CLI Python apps globally so they appear on your PATH and run like native binaries.
- Use uvx to run tools on demand without preinstalling them for quick, reproducible execution.