The Stem Cell Podcast

Ep. 310: “Epithelial Organoids” Featuring Dr. Hans Clevers

5 snips
Dec 9, 2025
Dr. Hans Clevers, a leading expert in molecular genetics, discusses the fascinating world of epithelial organoids, including innovative projects like snake lung organoids. He shares insights on the transition from academia to the pharmaceutical industry, emphasizing the complexities of developing cell therapies. Clevers also touches on the importance of simplicity in research, the value of organoids for drug testing, and the significance of mentorship and collaboration in scientific success.
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INSIGHT

Organoids As Pragmatic Discovery Tools

  • Hans Clevers frames organoids as pragmatic, opportunistic tools built by testing simple systems across many tissues.
  • He emphasizes growing epithelial organoids from patient material to discover robust, reproducible patterns.
ANECDOTE

Snake Lung Organoids Led To Virus Studies

  • A postdoc in Clevers' lab grew snake lung organoids unexpectedly after attempting snake gut.
  • They repurposed the model to study a Nidovirus that infects snake lungs.
ADVICE

Stop Projects Early To Save Resources

  • Prioritize stopping projects over starting new ones; costs multiply at each development stage.
  • Evaluate realistic odds early and terminate low-chance projects quickly to conserve resources.
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