The Challenges of Stimulant Dosing

Stimulant dosing for adult patients with ADHD raises concerns due to the difficulty of diagnosing the condition and the potential for overuse. While stimulants are highly rewarding and effective for treating real ADHD, off-label use can lead to imperfect effects and the need for higher and higher doses. The risks of going beyond recommended doses include abuse, cardiovascular problems, worsened cognition, and increased likelihood of psychiatric issues like psychosis and mania. Animal studies indicate neurotoxic damage at high doses of amphetamines, particularly above 60 mg per day.