Dr. Rountree discusses the positive effects of photobiomodulation on Alzheimer's patients, comparing it to Agile which doesn't improve mental performance. The podcast explores different locations for light therapy, penetration of light through the skull, and the benefits of pulsing the light. It also discusses the effects of pulsing light on the brain in mouse models of Alzheimer's disease.
Different methods of applying light to the brain for potential laser therapy protocols in Alzheimer's patients
Recommended parameters for laser therapy in Alzheimer's include specific wavelengths, irradiance, and treatment frequency
Deep dives
Application of Light: Location and Penetration
The researchers discuss three methods for applying light to the brain: using light on circulation-rich zones (axillary area, wrist, groin) to have downstream effects on memory disorders, utilizing light therapy on bones to mobilize stem cells, and delivering light through the skull (occiput) to reach the brain. They mention the optical tissue window that allows wavelengths of light between 650 and 1200 nanometers to penetrate through skin and skull. The researchers recommend using an 800 to 810 nanometer wavelength for penetration through the skull and a 970 to 1064 nanometer wavelength for deeper penetration into brain tissues.
Dosage and Irradiance
To achieve a therapeutic dose, the researchers suggest applying a dose in the range of 5-10 joules per centimeter squared at the cortex level, which corresponds to applying 25-60 joules to the scalp due to energy decrease during transcranial application. They also recommend pulsing the light at alpha and gamma frequencies (10 and 40 hertz) for improved results. In terms of irradiance, they suggest using an irradiance of up to 250 milliwatts per centimeter squared.
Treatment Protocol Considerations
The researchers emphasize the importance of treating a larger region to ensure thorough illumination. They mention that treating a smaller region may result in inadequate light exposure to the targeted areas. While they acknowledge that they do not cover the optimal treatment region and frequency, they note that many studies find benefits from treating three times a week, and one to two times a week for longer periods to maintain positive effects. They also mention that higher power and larger spot sizes in class four lasers can help maximize light penetration through the skull and deliver faster treatments.
This is a continuation of the previous episode on Alzheimer's. Today Dr. Rountree distills guidelines proposed in this new research to unlock a potential laser therapy protocol for Alzheimer's patients.