Business Of Biotech

Engineering B Cells With Immusoft's Sean Ainsworth

5 snips
Dec 8, 2025
Sean Ainsworth, CEO and Chairman of Immusoft, shares his experiences transitioning from a lab to biotech entrepreneurship. He discusses the promise of engineered B cell therapies for lysosomal storage diseases, highlighting the benefits over traditional enzyme replacement therapies. Ainsworth delves into his journey through M&A, the future of gene therapies, and regulatory frameworks. He also elaborates on the streamlined patient experience of his therapies, aiming for safer, redosable options, and advancing candidate indications.
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ANECDOTE

Early Startup Exit From University IP

  • Sean founded Compendia Bioscience from university IP and sold it to Thermo Fisher for $50M.
  • They raised little capital and achieved revenue early, which helped the exit.
ANECDOTE

Optogenetics Company Led To Major Acquisition

  • Sean launched RetroSense using optogenetics IP from Wayne State and dosed its first patient.
  • Allergan acquired the company after clinical dosing based on encouraging early data.
ADVICE

Always Build Toward An Exit

  • Build your company with an exit in mind by engaging industry early and often.
  • Use board and conference introductions to familiarize potential acquirers with your progress.
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