OncoPharm Clinical Trial Endpoints in Oncology
Jun 25, 2020
Dive into the essentials of clinical trial endpoints in oncology! Discover the significance of overall survival and quality of life as key priorities. Explore when to use overall survival metrics, and understand the nuances of progression-free survival. Learn about the role of surrogate endpoints and their impact on trial results. John Bazar breaks down disease-free and event-free survival concepts, while also highlighting response rates in various treatment scenarios like CAR-T. It's an informative ride perfect for newcomers to oncology!
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What Really Counts In Oncology
- Overall survival and quality of life are the outcomes that truly matter in oncology trials.
- Overall survival remains the gold standard despite other commonly used endpoints.
Ask If Disease Is Curable First
- Ask whether the disease is curable before judging the appropriate endpoint for a trial.
- Use median overall survival or landmark survival depending on cure potential and long-term toxicities.
Hodgkin's Regimen Divergence Over Time
- The ABVD versus MOP Hodgkin's study looked similar early but diverged by eight years due to secondary leukemias.
- Late toxicities changed long-term survival despite similar initial cure rates.