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OpenAI–AMD Deal, DevDay Reactions, xAI’s Memphis Datacenter | Doug O'Laughlin, Celine Halioua

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Oct 6, 2025
Doug O'Laughlin, President of SemiAnalysis, delves into OpenAI's ambitious partnerships with major tech players like AMD and the implications for chip supply dynamics. He offers insights into funding AI infrastructure and the evolving landscape of semiconductor investments. Celine Halioua, CEO of Loyal, shares her pioneering work on FDA-directed longevity drugs for dogs, discussing the potential crossovers to human health. She highlights the regulatory advantages of canine trials and the significance of operational excellence in therapeutic development.
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ADVICE

Plan For Agent Costs Before Scaling

  • Treat OpenAI's Agent Builder as the start of a prosumer market between free consumer apps and enterprise APIs.
  • Consider whether workflows you build will incur steady inference costs before scaling them into paid products.
INSIGHT

API First Signals Creative Tool Strategy

  • Releasing Sora 2 via API suggests OpenAI sees Sora mainly as a creative tool rather than a locked social network.
  • OpenAI likely prioritized rapid distribution of the model to enable broad content creation rather than hoard a consumption platform.
INSIGHT

AMD Deal Trades Purchases For Warrants

  • The AMD deal ties OpenAI purchases to warrants: OpenAI may receive pennies-per-share warrants that vest on deployment milestones.
  • This structure effectively transfers equity upside to OpenAI in exchange for committed chip purchases.
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