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The Curious Clinicians
80 - A Scleroderma Crisis
Nov 8, 2023
This podcast explores the effectiveness of ACE inhibitors in treating scleroderma renal crisis, highlighting the reduction in mortality rates. It delves into the mechanisms of bilateral nephrectomy and ACE inhibitors in the disease. The physiology of scleroderma crisis and potential treatment options are discussed, including the discovery of Capripl through ACE inhibition. The use of ACE inhibitors in managing vasoconstriction associated with elevated renin levels is also explored.
18:10
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Quick takeaways
- ACE inhibitors effectively treat scleroderma renal crisis by addressing vasoconstriction caused by elevated renin levels.
- Before the availability of ACE inhibitors, bilateral nephrectomy was used as a treatment for scleroderma renal crisis, but with limited success.
Deep dives
Improved Survival with ACE Inhibitors in Scleroderma Renal Crisis
The use of ACE inhibitors has greatly improved the survival of patients with scleroderma renal crisis. The condition is associated with elevated renin levels, and ACE inhibitors address the resulting vasoconstriction.
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