The New Statesman | UK politics and culture
"It's guided by six rats": The battle for a life-changing drug
Feb 5, 2025
Hannah Barnes, Associate Editor at the New Statesman, and Dr. Dominic Heaney, a neurologist consultant at UCL, tackle the critical issues surrounding valproate, a medication vital for epilepsy treatment. They explore the devastating consequences of valproate on unborn children, discussing rising congenital disorders and the implications of outdated prescribing guidelines. Dr. Heaney raises alarm over the current medical regulations affecting male patients, emphasizing the need for better communication and updated practices to ensure patient safety.
28:46
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Quick takeaways
- Valproate, though effective for seizure control, poses significant risks to fetal development that were historically not communicated to women.
- Recent changes in prescribing guidelines for Valproate may have overcorrected, creating barriers to necessary treatments for epilepsy.
Deep dives
The Lifelong Impact of Valproate Prescriptions
Valproate, an effective medication for managing seizures, carries significant risks, particularly for women who are pregnant. It is known to affect fetal development, with about 11% of children born to women taking this drug experiencing major congenital disorders. Many women, including Janet Williams, were not adequately informed of these risks when they were prescribed Valproate, which has led to lifelong consequences for their children. This lack of communication has resulted in various developmental issues, including withdrawal symptoms at birth and increased risks for disorders such as autism and educational difficulties.
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