The New Statesman | UK politics and culture "It's guided by six rats": The battle for a life-changing drug
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Feb 5, 2025 Hannah Barnes, Associate Editor at the New Statesman, and Dr. Dominic Heaney, a neurologist consultant at UCL, tackle the critical issues surrounding valproate, a medication vital for epilepsy treatment. They explore the devastating consequences of valproate on unborn children, discussing rising congenital disorders and the implications of outdated prescribing guidelines. Dr. Heaney raises alarm over the current medical regulations affecting male patients, emphasizing the need for better communication and updated practices to ensure patient safety.
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Janet's Story
- Janet Williams began taking valproate at 15 for epilepsy but wasn't informed of pregnancy risks.
- Her sons experienced withdrawal symptoms and developmental issues, later linked to fetal valproate syndrome.
Balancing Risks
- Valproate is vital for controlling seizures in some individuals, but carries risks for unborn children.
- New restrictions aim to prevent harm, but some neurologists worry they're over-correcting, particularly for men.
Evidence for Men's Risks
- Studies on rodents suggest potential transgenerational effects of valproate.
- One human study indicated a possible increased risk of developmental disorders in children of men taking valproate.