Mast Cell Matters: Deep dives on MCAS with Tania Dempsey, MD - Presented by The POTScast GI Manifestations of MCAS with Dr. Leonard Weinstock
Nov 8, 2023
Dr. Leonard Weinstock, a gastroenterologist and MCAS expert, delves into mast cell dynamics within the GI tract. He explains how high mast cell counts link to conditions like SIBO, IBS, and bloating. Weinstock shares insights on using low-dose naltrexone for treatment, highlighting its benefits and dosing complexities. Dietary strategies for MCAS management are discussed, including gluten-free and low FODMAP options. Furthermore, he explores the challenges of diagnosing IBS versus MCAS, emphasizing the importance of thorough medical education for better patient outcomes.
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Mast Cells' Role in GI Tract
- Mast cells are abundant in the gut where the environment meets the digestive tract and play a key role in MCAS symptoms.
- Their secreted chemicals cause local and systemic effects, often leading to bloating and other issues.
SIBO Triggers and Inflammation
- SIBO triggers inflammation activating mast cells and cytokine secretion, worsening MCAS symptoms.
- Treating SIBO can reduce systemic inflammation and associated conditions like restless leg syndrome.
Testing and Treating SIBO Types
- Determine SIBO type by breath tests (hydrogen, methane, hydrogen sulfide) and symptoms like gas odor.
- Tailor treatment using specific antibiotics or herbal therapies such as oregano for different SIBO types.