Smallpox was the most feared disease in North America and in many parts of the world before its eradication in 1980. So how did early Americans live with smallpox and work to prevent it? How did they help eradicate this terrible disease?

Over the next two episodes, we’ll explore smallpox in North America. We’ll investigate how smallpox came to North America, how North Americans worked to contain, control, and prevent outbreaks of the disease, and how the story of smallpox is also the story of immunization.

In this episode, we join experts Dr. René Najera, Farren Yero, Ben Mutschler, and Andrew Wehrman for a journey through the history of smallpox and the world’s first immunization procedure: inoculation.