Brom Rector and Sam Tabone from XEIA get specific on what Human 3 actually looks like in practice by analyzing 10 startups through the Human 3 lens.

We analyze the companies on the 5 pillars of Human 3

Distribution shifting potential - can this company elevate the already healthy in addition to healing the sick?
HERO - is the company inspired by Historical Examples of Real-world Outcomes
Step Change potential - if this thing works, will it be an order of magnitude better than the standard of care?
Endogenous Accelerant - does the company have a built in flywheel?
X-disciplinarity - does the innovation happen at the intersection of multiple disciplines?

Timestamps and companies mentioned:

0:00 - what defines a Human 3 startup?

16:00 - Mindstate Design Labs: AI designed psychedelic therapies

25:00 - Kadence Bio: treatment for premature ejaculation

34:20 - NeuroBionics: minimally invasive deep brain stimulation for Parkinson's

42:00 - Motif Neurotech: minimally invasive TMS for depression

51:45 - Xylo Bio: non-hallucinogenic psychedelics

1:01:45 - Pangea Bio: AI to identify natures hidden cures

1:11:00 - Kerna Labs: AI model to unlock the therapeutic potential of mRNA

1:20:00 - Superpower: concierge longevity medicine on your iPhone

1:30:00 - Coherence: closed loop neuromodulation to treat brain cancer (Glioblastoma)

1:40:27 - Beond: treating Opiate addiction with Ibogaine

1:52:00 - closing thoughts

Episode 28: Interview with Clay Scroggins