Episode 453: All About Inflammation

Jul 14, 2025

Dive into the fascinating world of inflammation! Learn how it plays a role in healing and chronic disease, plus signs you might be facing, like joint pain and brain fog. Discover the risks of common NSAIDs and the benefits of alternatives like omega-3s, turmeric, and dietary changes. Unlock the secrets of key inflammatory chemicals and testing methods. Find out which anti-inflammatory foods to stock up on and how proteolytic enzymes can aid tissue repair. This episode is packed with insights for a healthier, inflammation-free life!

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INSIGHT

When Inflammation Stops Helping

Inflammation is a necessary healing response but becomes harmful when chronic and systemic.
Chronic inflammation drives fatigue, body fat accumulation, joint pain, and broader metabolic dysfunction.

INSIGHT

Three Phases Of The Immune Response

White blood cells coordinate locating, fighting, and cleaning up infection or injury in three phases.
Neutrophils arrive first, macrophages perform phagocytosis, and later cells trigger repair and scar formation.

INSIGHT

Chemical Drivers Of Pain And Swelling

Inflammatory mediators include cytokines, leukotrienes, and prostaglandins with distinct effects.
Prostaglandins derived from arachidonic acid drive pain, fever, and vasodilation and respond to omega-6/omega-3 balance.

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This episode takes a deep dive into the complex world of inflammation—how it shows up in the body, its essential role in immune response and healing, and what happens when it becomes chronic. Listeners will gain insight into the signs of systemic inflammation, including joint pain, brain fog, skin issues, and digestive symptoms, along with a breakdown of how inflammation can become a driver of chronic disease when left unchecked.

We also examine the risks associated with common over-the-counter anti-inflammatory medications like NSAIDs, including their impact on gut integrity and long-term health outcomes. The episode offers evidence-based alternatives for pain and inflammation, including food-as-medicine strategies, targeted supplementation (like omega-3s, curcumin, and boswellia), and lifestyle practices that promote healing and regulate immune function without unwanted side effects.

Also in this episode:

Preorder Naturally Nourished Kids
What is inflammation?
Cellular shifts and the inflammatory cascade
Primary inflammatory chemicals
Testing markers of inflammation
- hs-CRP
- CRP
- ESR
Concerns with antiinflammatory medications
Steroids and their side effects
Top antiinflammatory supplements
Proteolytic Enzymes
- Inflammazyme
What to eliminate to reduce inflammation
- MRT Test
- The Best Food Sensitivity Test [Everly, Pinner or MRT]
Food as medicine support
- Fatty Fish
- Berries
- Olive Oil
- Turmeric
  - Lemon Turmeric Shooter
- Avocados

Sponsors for this episode:

This episode is sponsored by Wild Foods, a company that puts quality, sustainability, and health first in all of their products. They have everything from coffee to turmeric to medicinal mushrooms, and every single product is painstakingly sourced from small farms around the globe. They take their mission seriously to fix the broken food system, and believe real food is medicine. They've partnered with us to give you guys an exclusive discount, so use the code ALIMILLERRD for 12% off your order at WildFoods.co!