Influenced to Death Episode #45: MTHFR
Oct 22, 2025
Dr. Sarah Russell, a clinician and researcher, dives into the nuances of the MTHFR gene and its variants. She highlights its impact on health issues like autism, infertility, and the importance of methylation in the body. Through discussions on folate, homocysteine levels, and the pros and cons of prenatal supplements, the conversation emphasizes practical insights for patients. Dr. Russell also calls for a broader clinical perspective, urging healthcare providers to consider multiple factors rather than fixate solely on MTHFR.
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Methylation Is A Broad, Networked Process
- Methylation moves methyl groups (one carbon + three hydrogens) around the body to change molecules and regulate processes.
- Hundreds of genes and many nutrients coordinate methylation, making it a complex systemic network.
Prioritize Cofactors And Food First
- Support methylation by ensuring adequate cofactors: B2, B6, B12, choline, betaine and minerals.
- Focus on food first and aim for dietary diversity to provide required nutrients before high-dose supplementation.
Immune Quirks And Violent Sneezing
- Dr. Sarah Russell described having a hyper-reactive immune system nicknamed 'Don Quixote' with violent sneezing and allergic issues.
- She links her histamine symptoms to hypermobility and connective tissue remodeling needs.