#257 'Hope Through Science', Dr Jacqueline Orian Senior Research Fellow at La Trobe University

We’re pleased to welcome Dr Jacqueline Orian, Senior Research Fellow at La Trobe University, to a conversation exploring her work on a new approach to autoimmune disease—along with the habits and values that help sustain a career in scientific research.

While medical research is often associated with labs and data, Dr Orian sees value in slowing down and stepping outside. A long walk across campus or a quiet moment among La Trobe’s gardens is part of her routine. “Walks are very important,” she says. “Smelling the flowers, taking the long way between buildings—it’s important to make time for that.”

Even with a daily forty-minute commute, she finds time for reading, crafts, and music. While she sometimes works from home—especially for virtual interviews—she prefers the pace and energy of the lab, where she works alongside students and colleagues on new ideas and experiments.

Her current research focuses on platelets, the small blood cells known for their role in clotting. But her team has uncovered evidence that platelets are also involved in the progression of autoimmune diseases—conditions like multiple sclerosis (MS), where the immune system attacks the body’s own tissues.

In MS, current treatments can slow disease progression, but they often suppress the immune system more broadly. This makes patients more susceptible to infections and can come with other side effects.

Dr Orian is working on a more targeted alternative. Rather than suppressing the whole immune system, her aim is to modulate the role of platelets, reducing their contribution to damaging immune responses without compromising overall immune function. “Blocking a process is a bit of a sledgehammer approach,” she explains. “We’re aiming for something more precise.”

Her goal is to develop a platelet-targeting drug that limits tissue damage and slows or prevents disease progression. Within the next two years, she hopes to identify a promising molecule and generate early proof-of-concept data. If successful, this could offer a safer and more effective treatment option for MS and potentially other autoimmune conditions.

This research also has implications beyond MS. Because platelets are involved in various immune pathways, there may be opportunities to apply this approach to a broader range of immune and neurological disorders.

Dr Orian shares her findings through international conferences and collaborative networks, helping her team’s work reach researchers in other disciplines. “There’s a lot of opportunity for conferences,” she says. “It’s where knowledge is tested and shared.”

Mentorship is another key part of her role. She works closely with students in the lab, encouraging them to contribute ideas and take ownership of their research. “Their curiosity fuels mine,” she says—highlighting the value of working in an environment that supports learning and shared progress.

Dr Jacqueline Orian’s work is part of a growing effort to move beyond one-size-fits-all treatments and toward more tailored, precise solutions for complex diseases. With a combination of scientific focus and a commitment to thoughtful, balanced work, she is helping shape the next generation of research in autoimmune health.