Rheumnow Podcast
ACR24 - LUPUS
Nov 22, 2024
Andrea Fava is an expert in lupus nephritis diagnostics, while Chris Winkup is a consultant rheumatologist focused on CAR-T therapy. They dive into the challenges of diagnosing lupus nephritis with new non-invasive biomarkers. The discussion highlights the impact of positive ANA patterns on liver disease, and the advancements in CAR-T therapy for targeting harmful B-cells. They also touch upon vaccination responses and the complexities surrounding neuropsychiatric lupus, emphasizing the need for enhanced patient-clinician communication.
45:47
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Quick takeaways
- The emerging role of fibroblasts in autoimmune diseases highlights new treatment opportunities targeting their activation and inflammatory transformation.
- Recent advancements in identifying urinary biomarkers may revolutionize lupus nephritis diagnostics, enhancing accuracy and patient management strategies.
Deep dives
Fibroblast Role in Autoimmune Diseases
Recent research highlights the emerging significance of fibroblast cells in autoimmune diseases, suggesting a 'fibroblast renaissance.' It has been identified that certain fibroblasts can become inflammatory in patients with rheumatoid arthritis, which then leads to disease progression and cartilage damage. Researchers have discovered transcription factors that can drive these inflammatory fibroblasts to become invasive, marking a shift in understanding their role beyond collagen production and fibrosis. This insight paves the way for potential new treatments targeting this fibroblast transformation in autoimmune conditions.
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