In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge welcomes back Dr. Cheryl Burdette—naturopathic physician, educator, and founder of Precision Point Diagnostics—for a deep dive into one of the most evidence-backed biomarker bundles in functional medicine: the Gut, Oxidation & Stress panel.

Dr. Burdette explains how ten underutilized but highly predictive biomarkers—including anti-LPS antibodies, zonulin, 8OHdG, F2-isoprostanes, glutathione, and more—can give clinicians a full-body snapshot of inflammation, leaky gut, immune dysregulation, and oxidative stress. She discusses how each marker ties into chronic conditions from cardiovascular disease to autoimmunity to neuroinflammation—and exactly how to intervene when these labs are out of range.

This is a must-listen masterclass for any practitioner working with chronic illness, mystery symptoms, or “normal” labs that don’t tell the whole story.

You’ll Hear Them Discuss:

Why LPS antibodies are one of the most predictive markers in medicine today
How oxidative stress contributes to cardiovascular disease, autoimmunity, and brain fog
What 8OHdG, zonulin, secretory IgA, and glutathione tell us about barrier integrity
The surprising links between gut dysfunction and GLP-1, mood, and immune balance
Case studies showing biomarker-guided interventions that worked
How to boost glutathione (and what forms work best)
When to re-test and what lab shifts to look for
Advanced testing for food sensitivity: IgG subclasses, complement, and tolerance vs. reactivity
Natural GLP-1 agonists, bitters, fiber, and bile as part of metabolic healing

Guest Bio

Dr. Cheryl Burdette, ND is a licensed naturopathic doctor, educator, and founder of Precision Point Diagnostics. She also serves as the Director of Education at Progressive Medical Center in Atlanta, GA, and teaches extensively through Rupa Health, Fullscript, and Origins Incubator. A leading authority in integrative immunology, oxidative stress, gut health, and functional diagnostics, Dr. Burdette is especially known for developing innovative testing strategies that link root causes to chronic conditions.

Her mission: make testing clinically useful, evidence-backed, and accessible—so practitioners can treat smarter and patients can heal faster.

Guest Details

Dr. Cheryl Burdette, ND

Clinic: Progressive Medical Center, Atlanta, GA
Lab: Precision Point Diagnostics
Educational Program: Origins Incubator
Course Mentioned: “Food Sensitivities, Gut Health & Detoxification: A Functional Medicine Approach” (Rupa Health)
Instagram/LinkedIn: (not widely active publicly)

Rupa Health Details:

Rupa Health's Website, LinkedIn, Instagram, YouTube
Rupa Health Reference Guide & Magazine

Referenced Biomarkers

Upcoming Course with Dr. Cheryl Burdette

Course Title: Food Sensitivities, Gut Health & Detoxification: A Functional Approach

Where: Rupa University
Instructor: Dr. Cheryl Burdette, co-founder of Precision Point Diagnostics

What You’ll Learn:

How to identify inflammatory triggers
The role of gut permeability and detoxification markers
Deep dives into the P88-DIY and Gut-Ox tests
Clinically useful strategies for dietary antigen testing
Sign up here: Rupa University Bootcamp

Timestamps

00:00 – Welcome back Dr. Cheryl Burdette

02:22 – Why oxidative stress and immune dysregulation need testing

05:30 – The origin of the Gut-Oxidation-Stress biomarker bundle

13:56 – Anti-LPS antibodies: why they matter, how they’re measured, how to treat

20:56 – What elevated zonulin tells us and how immunoglobulins help

26:01 – Secretory IgA and the gut-immune interface

30:44 – 8OHdG: the ultimate marker for DNA damage and detox load

33:51 – What causes high 8OHdG and what it means for mitochondria

34:48 – Glutathione explained: why it matters and how to raise it

41:06 – Retesting: when to run this panel again

41:53 – F2-isoprostanes and lipid-based oxidative stress

44:11 – High F2iPs can block hormones, omega-3s, and healing

45:37 – Diet and supplement strategies for lowering lipid oxidation

48:57 – Food sensitivity testing: IgG subclasses, complement, and beyond

52:58 – The role of bile acids and GLP-1 in detox and metabolic healing

56:30 – Natural GLP-1 agonists: bitters, berberine, glutamine, B vitamins

58:25 – Where to find Dr. Burdette and learn more

01:06:29 – Rapid fire: most predictive marker, non-medical dream job, and more

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