On the latest edition of 49ers Talk, Matt Maiocco and Laura Britt discuss the main reasons of concern for the 49ers heading into the 2021 NFL season, including if injuries will play a role for the second straight year, and if DeMeco Ryans will experience some growing pains as the new defensive coordinator. Plus, hear the second part of the interview with NFL historian John Turney, where he reveals his thoughts on Patrick Willis, Joe Staley and the upcoming NFL season.

(1:37) NFL issues new COVID-19 guidelines

(6:35) Will injuries play a factor in the 2021 season?

(9:50) Can the 49ers improve their pass rush?

(15:11) Should the fans worry about Ryans' first season?

(26:40) How concerning is the WR position?

(30:40) Turney on if Patrick Willis should be in Canton

(36:41) Turney reveals his thoughts on Joe Staley’s HOF case

(41:41) Turney examines the 49ers' chances in 2021

49ers' reasons for concern heading into the 2021 NFL season