In this special episode, hosts Medaya Ocher, Kate Wolf, and Eric Newman discuss the case for and against giving up—on life, vices, dreams, creative pursuits, jobs, relationships, exercise, and work. Their conversation is inspired by Adam Phillips’s recent book On Giving Up, in which the psychoanalyst observes that “we give things up when we believe we can change; we give up when we believe we can’t.” The hosts discuss what is acceptable to give up, their own fears of failure, both fictional and real-life inspirational quitters, and whether Bartleby was onto something when he said he’d prefer not to.