Why is it important to understand the 3-D structures of protein, why are they difficult to construct, and what is the nature of AlphaFold’s advance? Why is this so exciting and what further advances in medicine and the other biosciences may result? On the 30th November it was announced that the Artificial Intelligence computer programme AlphaFold had made a decisive breakthrough in the determination of the 3-D structures of proteins. The announcement was immediately hailed as one of the major scientific advances of the decade. To find out why, join a conversation between Yvonne Jones, Director, Cancer Research UK Receptor Structure Research Group, Professor Phil Biggin, Professor of Computational Biochemistry, and Charles Godfray, Director, Oxford Martin School, who will explore these fascinating issues.