The Cribsiders S6 Ep116: Hemolytic Uremic Syndrome
Jul 31, 2024
In this discussion, Dr. Myda Khalid, a pediatric nephrologist from Indiana specializing in hemolytic uremic syndrome (HUS), sheds light on this serious condition often triggered by E. coli infections. She discusses the critical importance of recognizing HUS in pediatric emergencies, especially in cases with bloody diarrhea. Dr. Khalid explains the nuances of stool testing and the pivotal role of timely interventions like fluids and transfusions. Insightful case studies and current research trends further highlight the complexities of managing HUS in young patients.
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Early Testing for Shiga Toxin E. coli
- In children under five with acute bloody diarrhea in summer, always test for Shiga toxin-producing E. coli using stool culture or GI pathogen panel.
- Early detection and laboratory testing are crucial for diagnosis and closer patient monitoring to prevent progression to HUS.
Shiga Toxin Causes Bloody Diarrhea
- Shiga toxin-producing E. coli causes bloody diarrhea by damaging intestinal lining through the Shiga toxin.
- Blood appears in stool as the toxin directly harms cells, with symptom onset a couple days after infection.
Pathology of HUS Kidney Injury
- Shiga toxin enters blood, damages small vessel endothelium, triggering microthrombi which consume platelets.
- Resulting hemolytic anemia and kidney microthrombi cause acute kidney injury in about 60% of affected children.