Sabrina Gmuca, MD, MSCE, and David Sherry, MD, pediatric rheumatologists at Children’s Hospital of Philadelphia, explain the intense pain experienced by children with amplified musculoskeletal pain syndrome (AMPS), common causes and presentations of amplified pain, and evidence-based interventions that can help manage pain in these patients. Published November 2019. This podcast is for general informational and educational purposes only and is not to be considered as medical advice for any particular patient. Clinicians must rely on their own informed clinical judgment in making recommendations to their patients. ©2019 by Children's Hospital of Philadelphia, all rights reserved.