For nearly 20 years, I have strongly suspected that I have a genetic disorder in synthesizing or recycling something that is absent or poorly available from plant foods, is very rich in organ meats, and is not present in any of the supplements I was taking when I was a vegan.

After six months of research, testing, and self-experimenting, I now believe what I have been looking for is a mix of moderate genetic defects in biotin recycling, possibly combined with poor cellular uptake of biotin, and definitely combined with a defect in burning long-chain fatty acids for energy. The treatments for this, which I will be testing one at a time, will be high-dose biotin, high-dose riboflavin, possibly high-dose L-carnitine and glycine, and, if needed, an otherwise low-fat diet supplemented with C8-specific MCT oil.

This episode covers the content of the first of two articles I have written up on Substack.

First, I have a free gift for you: my MTHFR Protocol. This 7-page quick guide to optimizing your MTHFR status using foods and supplements is freely available to all subscribers to my Substack. Subscribe now and you will immediately get it emailed to you in the welcome email. You can subscribe here:

https://chrismasterjohnphd.substack.com/p/mthfr-protocol

The content of this episode can be found in the written version, with live links, here:

https://chrismasterjohnphd.substack.com/p/getting-to-the-bottom-of-my-health

The second article that will be covered in the next episode is about my self-experiments between September 2022 and June 2023 in the "biochemically unoptimized state" and can be found here: https://chrismasterjohnphd.substack.com/p/self-experiments-in-the-biochemically

“I’m dealing with a #$%*ing global crisis” (with John Heilemann)