This episode discusses the case of an 85-year-old man with a history of hypertension and fairly recently diagnosed bladder cancer who presents with oligoarticular asymmetric inflammatory arthritis. Explore the details of this case and learn how bacillus Calmette-Guérin and reactive arthritis are related in this diagnostic conundrum.
- Intro :10
- An 85-year-old man with a history of hypertension and recently diagnosed bladder cancer presents with oligoarticular asymmetric inflammatory arthritis :18
- Details of his cancer history :32
- How BCG (bacillus Calmette-Guérin) is used for superficial bladder cancer :53
- Patient wakes with acute onset, rapidly progressing joint pain 1:21
- Results of synovial aspiration of his right wrist 2:06
- Physical exam findings and patient history 2:24
- Discharged from outside hospital 2:53
- Outpatient rheumatologist orders autoimmune serologies 3:03
- Second hospital admission 3:24
- Infectious disease evaluation 4:25
- Patient presents to Cleveland Clinic 4:54
- What do we have? 6:18
- The main concern is he’s been instilled with bacteria 6:45
- Could this be a reactive arthritis? 7:18
- History of BCG 7:45
- What do we know about what happens to these patients? 10:28
- How do we define disseminated BCG infection vs. a reactive arthritis? 10:58
- A single institution cohort of disseminated infection after BCG instillation 11:29
- Comparing these definitions in our patient 14:34
- A look at reactive arthritis 15:07
- What do we use to treat these patients? 16:12
- A look back at our patient 16:31
- Continued treatment with triple therapy 17:05
- A diagnostic conundrum 17:32
- The diagnosis, in hindsight 18:11
- Summary 18:49
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References:
Bernini L. Autoimmun Rev. 2013;12:1150-1159.
Meyer J. Postgrad Med J. 2002;78:449-454.
Pérez-Jacoiste Asín MA. Medicine (Baltimore). 2014;93:236-254.