The Curbsiders Internal Medicine Podcast

#140 Psychopharmacology 2.0 - Antidepressant Master Class

4 snips
Feb 18, 2019
Dr. Patrick Finley, a professor of clinical pharmacy at UCSF and expert in psychopharmacology, dives into the nuances of treating depression. He shares practical tips on switching antidepressants and managing withdrawal symptoms. They explore strategies for handling persistent depression and the complexities involved in antidepressant transitions, particularly during pregnancy. The discussion also touches on the role of genetic factors in medication response, emphasizing a tailored approach for patient care.
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ADVICE

Target Symptoms

  • Consider a patient's target symptoms when choosing antidepressants.
  • For example, patients with atypical depression may respond well to norepinephrine or dopamine increasing agents like bupropion.
INSIGHT

Family History Matters

  • Responses to antidepressants appear to have a genetic component and run in families.
  • Consider a patient's family history when selecting a medication.
ADVICE

Check Ferritin

  • Check ferritin levels in patients failing SSRI/SNRI therapy.
  • Iron is necessary for neurotransmitter synthesis, so insufficient levels may hinder treatment efficacy.
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