Core IM | Internal Medicine Podcast #136 How Did Diabetes Medications Become Obesity Meds? Beyond Journal Club on SURMOUNT-1 Trial
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Oct 4, 2023 #136 How Did Diabetes Medications Become Weight Loss Meds? SURMOUNT-1 trial explores the difference between semaglutide and tirzepatide in outcomes and mechanism. Discussion on the history of obesity treatment and how medications for diabetes were found to have a weight loss benefit. The effectiveness of tirzepatide as a weight loss drug compared to semaglutide. Speculations on future medications with similar potential.
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Obesity as Environmental Disease
- Obesity is better understood as an environmental disease influenced by obesogenic surroundings.
- This shifts focus from blame to aiding patients effectively in a challenging environment.
Incretin System Drives Weight Loss
- The Incretin system hormones GLP-1 and GIP regulate appetite and blood sugar naturally.
- Drugs mimicking these hormones reduce hunger and cause weight loss by targeting this system.
Weight Loss: A Happy Accident
- Diabetes drugs like semaglutide (Ozempic) were developed mainly to control blood sugar, not for weight loss.
- Their unexpected weight loss benefits were a happy accident discovered during clinical trials.