

TWiV 1197: The long and short of influenza
Mar 2, 2025
The conversation covers the recent passing of a pioneering virologist and the ongoing health crisis in Congo linked to a deadly illness. The hosts discuss alarming trends in vaccine funding disruptions and the implications for public health. A deep dive into H5N1 influenza reveals unique genetic features affecting transmission potential. They also explore the durability of vaccines, including the role of adjuvants, and share insights on enhancing immune responses. Lastly, a light-hearted interaction about space travel captivates the audience.
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Beaded Genome
- Vincent Racaniello recalls Ann Palmenberg gifting him a poliovirus model.
- Later, she made him a beaded rhinovirus genome, followed by a beaded poliovirus genome.
Congo Illness
- A deadly illness in western Congo has caused rapid deaths, with some occurring within two days of symptom onset.
- Tests for Ebola and Marburg virus are negative, but many infected individuals also have malaria.
USAID Disruption
- The disruption of USAID programs has impacted the mpox outbreak response in the DRC, creating an illusion of improvement while cases increase.
- The same disruption has also severely hampered Ebola prevention and response efforts, particularly in Uganda.