GasGasGas - The FRCA Primary Exam Podcast VivaCast 14 - Kinetics, Hypoglycaemics and Drug Trial fun!
Mar 27, 2025
Dive into the world of pharmacokinetics, where drug absorption, distribution, metabolism, and excretion are unraveled. Discover the intricacies of hypoglycaemic medications, including insulin's roles and risks. Explore the fascinating landscape of clinical trials, from randomized controlled designs to the evolution of drug development phases. Gain insights on the balance between efficacy and safety, punctuated with an understanding of statistical analysis through meta-analysis. Perfect for anyone looking to sharpen their medical knowledge!
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Pharmacokinetics: The Four Key Stages
- Pharmacokinetics describes what the body does to a drug across absorption, distribution, metabolism and excretion.
- These stages determine onset, duration, tissue targeting and accumulation risk in different patients.
Account For Route And First-Pass
- Consider route and first-pass metabolism when predicting oral drug effect and dose.
- Remember IV administration gives 100% bioavailability while some oral drugs (e.g., vancomycin) have near-zero bioavailability.
Liver Enzymes Alter Drug Fate
- Liver enzyme activity changes drug metabolism and can be induced or inhibited by other drugs.
- This alters drug effect and duration, so check for interactions when prescribing.