The Intern At Work: Internal Medicine
240. A not so nice ring to it: An Approach to Salicylate toxicity
Jun 10, 2024
Dr. Bonisteel, Dr. Laird, Dr. Howes, and Sapriya Birk discuss the history, pharmacology, and clinical management of Salicylate Toxicity. Topics include the origins of salicylates, discovery of aspirin, toxic effects, criteria for dialysis, altered mental status, severe acidosis, acute kidney injury, and a case of tinnitus after ingestion.
17:20
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Quick takeaways
- Salicylate toxicity manifests through various symptoms impacting multiple body systems.
- Diagnosis and treatment of salicylate toxicity involve specific clinical assessments and supportive measures.
Deep dives
Evolution of Salicylates from Ancient Egypt to Modern Medicine
Salicylates derived from willow bark, with roots dating back to ancient Egypt, have been utilized for their pain-relieving and anti-inflammatory properties. The discovery of acetosicylic acid, known as aspirin, in the 1890s revolutionized salicylate usage due to its reduced irritant effects on the stomach, making it a widely preferred medication since then.
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