The Progress Theory The Molecular Physiology Of Hybrid Training - Professor Keith Baar
Hello and welcome to The Progress Theory where we discuss how to implement scientific principles to optimise human performance. In this episode we have Dr Keith Baar, Professor of Molecular exercise physiology at the University of California.
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One of the mechanisms for the interference effect when hybrid training is molecular signalling theory. When activated by endurance exercise the AMPK pathway may inhibit the mTOR pathway, inhibiting strength and hypertrophy adaptations. But what does this all mean? In this episode, Professor Baar and Dr Phil Price discuss how these molecular pathways get activated, why endurance training might inhibit strength training adaptations, and how we can change our programming to reduce this.
In this episode, we discuss:
- 1:14 - Introduction
- 6:03 - What is mTORC1 and AMPK?
- 10:43 - Factors which activate mTORC1 and AMPK
- 14:55 - The importance of leucine
- 18:35 - How long mTORC1 and AMPK stay activated poster exercise
- 21:53 - Molecular breaks
- 25:08 - Difference between rats and human studies on concurrent training
- 31:23 - Untrained vs trained
- 36:48 - Practical recommendations for hybrid athletes
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