In this episode Professor Harries discuss how she and her team used resveralogs initially and later HS2 donors to change the regulation of splicing factors and in doing so, reverse cellular senescence. We also touch on what a therapy based on this might look like in the clinic.

Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.

She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.

Professor Harries site at University of Exeter

https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries

Senisca home page

https://www.senisca.com/

If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.

Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/

10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/