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The Curbsiders Internal Medicine Podcast

#418 DIGEST (Tofurkey Edition): Semaglutide for HFpEF, TCAs for IBS, Aspirin vs Clopidogrel after PCI, Pitavastatin for HIV, Starchy Vegetables & Weight Gain, Heavy Metals in Cannabis

Nov 27, 2023
Drs. Paul Williams and Nora Taranto discuss semaglutide for HFpEF and obesity, TCAs for IBS, clopidogrel vs aspirin after PCI, pitavastatin in HIV, weight changes and diet, and heavy metal exposure in cannabis users.
01:03:06

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Quick takeaways

  • Pitivastatin statin may be an appropriate option for primary prevention of cardiovascular disease in HIV patients.
  • Choosing the right types of vegetables and avoiding starchy options can help with weight management.

Deep dives

Studying the Benefits of Pitivastatin Statin for Cardiovascular Disease in HIV Patients

The REPRIEVE trial investigated the use of pitivastatin statin in HIV patients who were at low to moderate risk of cardiovascular disease. The trial enrolled over 7,000 adults aged 40 to 75 who were taking antiretroviral therapy for their HIV diagnosis. The results showed that pitivastatin statin significantly reduced major adverse cardiovascular events compared to placebo, with a number needed to treat of 106. This suggests that pitivastatin statin may be an appropriate option for primary prevention of cardiovascular disease in this patient population.

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