#418 DIGEST (Tofurkey Edition): Semaglutide for HFpEF, TCAs for IBS, Aspirin vs Clopidogrel after PCI, Pitavastatin for HIV, Starchy Vegetables & Weight Gain, Heavy Metals in Cannabis
Nov 27, 2023
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Drs. Paul Williams and Nora Taranto discuss semaglutide for HFpEF and obesity, TCAs for IBS, clopidogrel vs aspirin after PCI, pitavastatin in HIV, weight changes and diet, and heavy metal exposure in cannabis users.
Pitivastatin statin may be an appropriate option for primary prevention of cardiovascular disease in HIV patients.
Choosing the right types of vegetables and avoiding starchy options can help with weight management.
Deep dives
Studying the Benefits of Pitivastatin Statin for Cardiovascular Disease in HIV Patients
The REPRIEVE trial investigated the use of pitivastatin statin in HIV patients who were at low to moderate risk of cardiovascular disease. The trial enrolled over 7,000 adults aged 40 to 75 who were taking antiretroviral therapy for their HIV diagnosis. The results showed that pitivastatin statin significantly reduced major adverse cardiovascular events compared to placebo, with a number needed to treat of 106. This suggests that pitivastatin statin may be an appropriate option for primary prevention of cardiovascular disease in this patient population.
The Association Between Carbohydrate Intake and Long-Term Weight Changes
A prospective cohort study examined the association between changes in carbohydrate intake and long-term weight changes. The study found that increasing intake of fiber, natural sugars, whole grains, fruit, and non-starchy vegetables was associated with less weight gain, compared to consuming refined grains, potatoes, starchy vegetables, and sugar-sweetened beverages. This highlights the importance of not only increasing vegetable intake but also choosing the right types of vegetables and avoiding starchy options for better weight management.
Cannabis use and heavy metal exposure
A study found that cannabis users have higher levels of lead and cadmium in their blood compared to non-users. Cannabis is a hyperaccumulator of heavy metals, and its high prevalence and lack of regulation contribute to the potential health risks associated with heavy metal exposure. The study highlights the need for awareness and caution when using cannabis, particularly in terms of potential heavy metal toxicity.
Clopidogrel vs. aspirin in post-PCI patients
A post hoc analysis of the host exam trial compared the use of clopidogrel and aspirin monotherapy in patients who had undergone percutaneous coronary intervention (PCI). The analysis showed that clopidogrel outperformed aspirin in terms of reducing adverse outcomes and ischemic events, regardless of the patients' risk scores. The findings support the use of clopidogrel as a preferred antiplatelet therapy after PCI, especially for patients at higher risk of clinical events.
Join us as we review recent articles and news featured in The DIGEST #45 and #46, including semaglutide in HFpEF and obesity (STEP HFpEF), TCAs for irritable bowel syndrome (ATLANTIS), clopidogrel versus aspirin as long-term secondary prevention after PCI (HOST-EXAM), statins in HIV (REPRIEVE), weight changes and diet, and heavy metal exposure in cannabis users. Fill your brain hole with a delicious stack of hotcakes! Featuring Drs. Paul Williams (@PaulNWilliamz), Nora Taranto (@norataranto), and Matt Watto (@doctorwatto).
Written and Hosted by: Nora Taranto MD; Paul Williams, MD, FACP, Matthew Watto MD, FACP
Cover Art: Matthew Watto MD, FACP
Reviewers: Nora Taranto MD; Paul Williams, MD, FACP; Matthew Watto MD, FACP; Sai Achi, MD MBA
Technical Production: Pod Paste
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Show Segments
Intro, disclaimer
STEP HFpEF: semaglutide for HFpEF in obesity
TCAs for IBS
HOST-EXAM and post-PCI clopidogrel versus aspirin after DAPT
REPRIEVE and pitavastatin in HIV
Starchy vegetables and weight changes
Cannabis and heavy metal content
Outro
Transcript Disclaimer
We've included a a free AI-generated transcript which has not been corrected by a human for accuracy or completeness. Please consider this a starting point for further research and consultation. We disclaim any liability for damages or losses resulting from this content.
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