JAMA Psychiatry Author Interviews Differential Outcomes Associated With Placebo Treatment Across 9 Psychiatric Disorders
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May 29, 2024 Tom Bschor, author of a study on placebo treatment across 9 psychiatric disorders, discusses the significant improvements seen under placebo treatments for disorders like major depressive disorder and generalized anxiety disorder. The podcast explores the methodology of analyzing placebo responses, emphasizing the importance of understanding variations in response and the impact of contextual factors on treatment effectiveness.
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Placebo Response Factors
- Psychiatric improvement isn't solely due to the placebo effect.
- Additional factors like episodic disorder course, contextual factors (attentive personnel, compassionate care), and conditioning effects contribute.
Varied Placebo Responses
- Placebo responses likely differ across psychiatric disorders due to varying factors.
- These include episodic nature, hope-building capacity, biological vs. psychogenic factors, etc.
Clinical Implications of Placebo Response
- Consider placebo response when treating patients and interpreting studies.
- Evaluate if active treatment is immediately necessary or if waiting is feasible.