Dr. Jack Kreindler on Human Performance, Longevity, and the Science of Flourishing.

What does it really mean to live longer—and better?In this deep and inspiring conversation, I sit down with Dr. Jack Kreindler, a physician, physiologist, and performance scientist who’s worked with elite athletes, founders, and some of the world’s most high-performing individuals. As the founder of Well Founded, Dr. Jack blends cutting-edge science with soulful insight to explore what makes us thrive—not just survive.We talk about:• 🧬 The real science behind longevity and healthspan• 🛌 Why sleep is still the best “regenerative medicine” on the planet• 🧠 The power of “firsts,” novelty, and challenge in slowing down time• 💊 Why sex, drugs, and rock & roll are key to well-being (yes, really)• 🦾 How to train for 90 like it’s your Everest—starting now• 🧘‍♂️ The role of eudaimonia (human flourishing) in modern medicine• 🔬 How Dr. Jack works with both ultra-high performers and people facing the end of life• 🏔️ Why discomfort, nature, and awe may be the real biohacksChapters:00:00:00 🎙️ Welcome and who is Dr Jack00:00:42 🧠 Medicine and physiology bodies when right wrong00:01:09 🏔️ Explorer mountains extremes and learning in the wild00:01:53 🎸 Sex drugs and rock n roll longevity idea00:04:06 🤝 Human connection oxytocin feeling loved00:05:21 🎯 Dopamine purpose goals ikigai drive to live00:07:33 ✨ Awe serotonin you cant infuse this live it00:09:39 📌 80 20 request practical longevity00:10:25 ⌚️ Wearables vs ICU when data actually helps00:12:15 🧭 Learn your own signals intuition over constant tracking00:14:10 🛠️ Use tech wisely dont miss silent killers00:14:50 🛏️ Your bed is the clinic sleep as regenerative medicine00:15:40 🛏️🏃‍♂️🥗😮‍💨 The big four sleep movement nutrition stress00:16:51 🎂 Aim 90 years old with a 60 year old physiology00:18:57 🧩 The five domains strength endurance aerobic Zone 2 balance mobility00:21:16 🧪 VO2 and strength greater than aging clocks Buck Institute00:22:50 🥗 Eat real food avoid ultra processed calories00:23:37 🧬 Biology vs willpower GLP 1 and appetite circuits00:24:34 📝 Mind tools gratitude and simple daily practices00:26:19 🌱 Beyond no disease team connectedness motivation00:29:59 🌟 Eudaimonia human flourishing definition and practice00:31:40 🔢 Why numeric goals 120 years 1B miss the point00:35:06 ❤️‍🩹 Serving 150 days vs 150 years care at both ends00:39:00 ⏳ Time is uncertain align goals with real risks00:44:23 🎯 Where do you want to be at 90 Alexs answer00:50:35 💪 150 percent physiology now 60 at 90 performance framing00:51:43 🧗 Experiential medicine discomfort appreciation00:53:27 ⚡ Can I challenge that The debate begins01:00:02 🎾 Tennis match intrinsic motivation vs entropy01:07:06 🏁 Cadence you cant redline all the time01:08:17 🔁 Do a lot then recover a lot the wave01:15:25 🌊 Life length amplitude of the wave not just time01:16:52 🆕 Create more firsts to slow time and deepen life01:20:39 🙏 Gratitude close lets go create some firstsFrom the physics of entropy to the neuroscience of joy, this episode will shift how you think about health, aging, and the deeper meaning of living well.Whether you’re a founder, a health geek, or just curious about how to stay vital into your 90s and beyond—this is the conversation for you.👉 Subscribe here: https://www.youtube.com/@AlexIkonnPodcast👉 Follow me on Instagram: https://www.instagram.com/alexikonn/👉 Brought to you by: https://link.intelligentchange.com/tools68894b