Ep. 2: Reprogramming Brakes and Government Shutdown Featuring Dr. Jacob Hanna
Oct 11, 2013
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Dr. Jacob Hanna, a distinguished scientist at the Weizmann Institute of Science, reveals his team's groundbreaking 100% efficiency in reprogramming somatic cells to pluripotent cells. The conversation dives into the delicate nature of embryonic stem cells and the critical role of mitochondrial functions in cellular processes. Additionally, the impact of the U.S. government funding crisis on scientific research is discussed, alongside innovative advancements such as CRISPR and the enhancement of reprogramming techniques. It's a deep dive into the future of stem cell science!
The government shutdown is critically impacting scientific research funding, causing delays and uncertainties for many projects reliant on federal support.
Innovative research on a new pill-based treatment for C. difficile infections offers a less invasive alternative to fecal transplants, enhancing patient care.
Deep dives
Impact of Government Shutdown on Scientific Research
The ongoing government shutdown has severely affected scientific research, particularly at institutions like the NIH and NASA. With a significant portion of NIH's budget being frozen, researchers face delays in grant reviews and support for ongoing projects. This leaves many scientists in limbo, especially those whose crucial experiments depend on federal funding. The situation has spurred concerns over the long-term implications for U.S. science competitiveness and has led to calls for a reassessment of funding priorities to ensure vital research projects can continue.
Fecal Transplant Alternative for C. difficile
Researchers have developed a new pill-based treatment for C. difficile infections, serving as an alternative to traditional fecal transplants. The innovative approach involves using antibiotics to eliminate harmful bacteria and then administering triple-coated pills that release beneficial bacteria directly into the colon, promoting repopulation of healthy gut flora. This advancement provides a less invasive and more patient-friendly option for managing severe intestinal conditions associated with C. difficile, which significantly impacts patients' quality of life. Researchers emphasize the importance of this method in improving patient outcomes and comfort during treatment.
New Insights into Embryonic Stem Cell Sensitivity
A study highlights the unique apoptosis mechanism in human embryonic stem cells that makes them more susceptible to DNA damage. Researchers found that embryonic stem cells exhibit a higher ratio of pro-apoptotic to anti-apoptotic proteins compared to differentiated cells, translating to a greater likelihood of cell death when damaged. This sensitivity may serve as a protective measure for early developmental stages, ensuring that compromised cells do not contribute to improper development. Understanding this phenomenon could have significant implications for cancer research and therapies aimed at preventing tumor formation.
Harnessing Pituitary Stem Cells for Regeneration
Groundbreaking research has identified and isolated stem cells within the pituitary gland, suggesting potential for endocrine regeneration in conditions such as growth hormone deficiency. The study demonstrated that these pituitary stem cells could be mobilized and expanded in vitro, exhibiting the ability to differentiate back into their original hormonal functions. This discovery opens avenues for developing therapies that could restore hormonal balance in individuals suffering from endocrine disorders. It represents a significant step forward in understanding the regenerative capabilities of the endocrine system and how to harness them for clinical applications.
Guest:
In this episode we welcome Dr. Jacob Hanna from Weizmann Institute of Science. Dr. Hanna’s group recently published in Nature describing a method for 100% reprogramming efficiency. We also do our usual Stem Cell Podcast roundup, which includes anti-acne bacteria, Eric Kandel’s RB-AB 48 Alzheimer’s target and others.
Photo Reference: Courtesy of Dr. Jacob Hanna
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