What hibernating bears and 'couch potato' cavefish are teaching us about blood clots and fatty liver disease
Mar 6, 2024
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Deboki Chakravarti, an expert on animal extremities and their health implications, dives into the fascinating survival strategies of hibernating bears and Mexican cavefish. She explains how bears avoid blood clots during hibernation and the potential treatments this offers for humans. The conversation extends to the cavefish, revealing their unique adaptations to starvation and darkness that could inform fatty liver disease research. Deboki also humorously ponders the strange case of a mushroom growing on a frog, highlighting the complexities of defining species.
Research on hibernating brown bears reveals a mechanism for reduced blood clotting, pointing towards potential treatments for venous thrombosis in humans.
Mexican cave fish demonstrate unique adaptations to nutrient scarcity that could inspire new strategies for preventing fatty liver disease in people.
Deep dives
The Evolution of Life on Earth
Earth's early environment was predominantly aquatic, forming a primordial soup that set the stage for life to evolve over billions of years. Initially, single-celled organisms emerged, leading to the development of multicellular plants and animals, and eventually, humans. Despite the vast differences in appearance and behavior among species, there is a significant genetic connection, suggesting that studying other species can offer insights into human biology and health. This evolutionary relationship highlights the potential benefits of examining the unique characteristics of various organisms to improve our understanding of human physiology.
Bear Hibernation and Platelet Function
Research into hibernating brown bears has revealed that these animals do not experience blood clotting issues during their prolonged periods of inactivity. Scientists collected blood samples from both active and hibernating bears to study the behavior of platelets, discovering that those in hibernation are significantly less reactive. A protein called heat shock protein 47 (HSP47) was identified as playing a crucial role in this process, as hibernating bears produce much lower levels of this protein compared to their active counterparts. Understanding this mechanism could lead to innovative treatments for venous thrombosis, which poses risks during periods of immobility in humans.
Mexican Cave Fish and Fatty Liver Disease
The Mexican cave fish has adapted to a nutrient-scarce environment, avoiding fatty liver disease despite being constantly starved. Researchers found that these fish reduce the production of a protein called fatty acid transport protein (fat P2), which protects them from accumulating fat in the liver, a condition common in other species under starvation. Interestingly, blocking fat P2 production in surface fish replicated these protective effects, demonstrating potential avenues for future treatments of fatty liver disease in humans. Additionally, studies on these fish have shown that they maintain physical fitness despite reduced muscle mass, revealing unique energy storage methods that could inform strategies to counteract the health effects of physical inactivity in humans.
Although we look very different from many of the other creatures on this planet, we’re more connected than you might think. Our evolutionary history means we share many of the same genes and physiology, and that’s not just cool to think about — it’s useful. Because it means that, to learn about the things we lack or wish we could do better, we can study the exceptional abilities of other animals.
In today's episode, Sam and Deboki cover two species with extreme lifestyles— brown bears and Mexican cave fish — and what they are teaching us about avoiding blood clots and fatty liver disease, and how that could unlock the potential for new treatments. In this week’s Tiny Show and Tell, Sam asks "What is a species?" and Deboki ponders how a mushroom could grow out of a living frog.
Links to the Tiny Show & Tell stories are here and here. Support the show by picking up a Tiny Matters mug here! All Tiny Matters transcripts are available here.
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