"Upstream" with Erik Torenberg

E78: Fertility, Healthy Humans, and Ending Genetic Disease w/ Noor Siddiqui, CEO of Orchid

Sep 19, 2024
Guest
Noor Siddiqui
In this insightful discussion, Noor Siddiqui, CEO of Orchid, delves into revolutionary advancements in reproductive technology, particularly the first whole genome embryo screening. She highlights the significant journey of improving genomic sequencing accuracy and how these innovations can drastically reduce genetic diseases. Noor addresses the evolving societal views on IVF and reproductive tech, navigating stigmas and ethical concerns while outlining a future where parenting norms may transform. Her passion for making fertility solutions accessible shines through as she shares Orchid's mission.
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INSIGHT

Whole Genome Embryo Sequencing

  • Orchid developed the first whole-genome embryo screening, sequencing 99% of the genome.
  • This upgrade from older methods, which sequenced less than 1%, allows for comprehensive disease risk assessment.
INSIGHT

From 1% to 99%

  • Orchid achieved whole-genome embryo sequencing by optimizing every step of the process, from sample handling to bioinformatics.
  • This dedication, combined with leveraging existing advancements, enabled this high-resolution screening.
INSIGHT

Advancements in Sequencing

  • Whole-genome sequencing became truly useful due to advancements in adult sequencing and growing datasets linking genetic variants to diseases.
  • A decade ago, even with a full genome readout, the available information would have been less insightful.
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